
Hyaluronic Acid + Niacinamide + Tretinoin 0.5%/4%/0.025%
- A topical skin-care formulation combining hyaluronic acid, niacinamide, and tretinoin for provider-guided skin treatment.
- Treatment requires review by a licensed healthcare provider and a prescription when clinically appropriate.
This topical formulation contains hyaluronic acid 0.5%, niacinamide 4%, and tretinoin 0.025%. Tretinoin is a topical retinoid used in prescription treatment of acne vulgaris, while the complete combination should be considered according to the specific formulation prescribed by your healthcare provider.
Use this topical formulation exactly as prescribed by your healthcare provider. Follow the product-specific application instructions supplied with your prescription, including where, how much, and how often to apply it.
Tretinoin may cause dryness, peeling, redness, irritation, or a temporary increase in skin sensitivity. Your provider should review your skin history and help determine whether this formulation is appropriate for you.
Your healthcare provider determines whether this formulation is appropriate based on your skin concerns, medical history, current medications, allergies, and individual treatment needs.

Start Your Skin Care
Care Journey
A simple, provider-guided process to determine whether this topical treatment may be appropriate for your skin-care needs.
- 1Get Started
Provide the information needed for a licensed healthcare provider to understand your skin concerns and treatment needs.
Start online
- 2Provider Review
A licensed healthcare provider reviews your information and determines whether this treatment may be clinically appropriate for you.
Prescription required
- 3Start Your Treatment
If prescribed, receive your topical treatment and follow the application instructions provided by your healthcare provider.
Provider-guided care




Important Things to Know
Before Starting Treatment
Review important considerations about the ingredients, application, skin irritation, sun sensitivity, and provider-guided treatment.
- Understanding the Three Active Ingredients
- How to Apply Your Prescribed Treatment
- Dryness, Peeling, and Skin Irritation
- Sun Exposure and Skin Sensitivity
- Skin Conditions and Health Considerations
- Monitoring Your Skin Response
Prescription skin treatment requires evaluation by a licensed healthcare provider. Treatment suitability, formulation, application instructions, and ongoing care vary by patient.
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Treatment Options
Explore other skin-care treatment options available through provider-guided care and review which approach may be appropriate for your needs.

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Your Skin Care
Step by Step
Your provider determines the appropriate treatment approach and may review your skin's response over time.

If prescribed, your provider will explain how to apply the formulation and review important precautions.
Use the treatment according to your prescription and product-specific application instructions.
Your provider may review your response, tolerance, and ongoing skin-care needs to determine the appropriate next step.
Treatment plans and application instructions vary by patient. Do not change your treatment without discussing it with your healthcare provider.
Frequently Asked Questions
It is a topical formulation containing hyaluronic acid 0.5%, niacinamide 4%, and tretinoin 0.025%. Tretinoin is a prescription topical retinoid used for the treatment of acne vulgaris. The suitability of the complete formulation depends on your individual clinical circumstances.
Topical tretinoin is indicated for the treatment of acne vulgaris. It works as a topical retinoid and helps reduce the formation of comedones by affecting the turnover and cohesiveness of follicular skin cells.
Yes. Tretinoin can cause dryness, redness, peeling, irritation, and increased sensitivity to sunlight. Your provider can help you understand how to use your prescribed formulation and manage treatment-related irritation.
Use the formulation exactly as prescribed and follow the instructions supplied with your medication. Do not change the amount or frequency of application without guidance from your healthcare provider.
The FDA-approved labeling for tretinoin 0.025% establishes topical use for acne vulgaris, but that does not establish FDA approval of this exact hyaluronic acid, niacinamide, and tretinoin combination. The specific formulation and its regulatory status should be confirmed with the dispensing pharmacy and healthcare provider before publication.
This product requires evaluation and a prescription from a licensed healthcare provider. Treatment selection and application instructions are individualized based on your skin concerns and clinical circumstances.